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May cause impairment of mineralocorticoid secretion; administer mineralocorticoid simultaneously. We also use third-party cookies that help us analyze and understand how you use this website. Always follow the prescription and instructions as exactly your Doctor wrote. With this formulation, the timing of the dose should consider the delayed-release pharmacokinetics and the disease or condition being treated (for example, the medication may be taken at bedtime to decrease morning stiffness with. Jurdy Dugdale is a Registered Nurse in Florida. You might notice thinning skin that bruises easily, redistribution of body fat, acne, and increased facial hair. 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